Cytoprotective Nrf2 pathway is induced in chronically txnrd 1-deficient hepatocytes.

ABSTRACT:

Background

Metabolically active cells require robust mechanisms to combat oxidative stress. The cytoplasmic thioredoxin reductase/thioredoxin (Txnrd1/Txn1) system maintains reduced protein dithiols and provides electrons to some cellular reductases, including peroxiredoxins.

Principal findings

Here we generated mice in which the txnrd1 gene, encoding Txnrd1, was specifically disrupted in all parenchymal hepatocytes. Txnrd1-deficient livers exhibited a transcriptome response in which 56 mRNAs were induced and 12 were repressed. Based on the global hybridization profile, this represented only 0.3% of the liver transcriptome. Since most liver mRNAs were unaffected, compensatory responses were evidently effective. Nuclear pre-mRNA levels indicated the response was transcriptiona

SUBMITTER: Suvorova ES 

PROVIDER: S-EPMC2703566 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature