Topical bevacizumab in the treatment of corneal neovascularization: results of a prospective, open-label, noncomparative study.

ABSTRACT:

Objective

To study the safety and efficacy of topical bevacizumab in the treatment of corneal neovascularization (NV).

Design

In a prospective, open-label, noncomparative study, 10 eyes from 10 patients with stable corneal NV were treated with topical bevacizumab, 1.0%, for 3 weeks and followed up for up to 24 weeks.

Main outcome measures

The primary safety variables were the occurrence of ocular and systemic adverse events throughout the course of the study. The primary efficacy variables were neovascular area, the area of the corneal vessels themselves; vessel caliber, the mean diameter of the corneal vessels; and invasion area, the fraction of the total corneal area covered by the vessels.

Results

From baseline visit to the last follow-up visit, mean reducti

SUBMITTER: Dastjerdi MH 

PROVIDER: S-EPMC2703579 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature