Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.

ABSTRACT: To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.

SUBMITTER: Ferreira MA 

PROVIDER: S-EPMC2703780 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature