Genomes2Drugs: identifies target proteins and lead drugs from proteome data.

ABSTRACT:

Background

Genome sequencing and bioinformatics have provided the full hypothetical proteome of many pathogenic organisms. Advances in microarray and mass spectrometry have also yielded large output datasets of possible target proteins/genes. However, the challenge remains to identify new targets for drug discovery from this wealth of information. Further analysis includes bioinformatics and/or molecular biology tools to validate the findings. This is time consuming and expensive, and could fail to yield novel drugs if protein purification and crystallography is impossible. To pre-empt this, a researcher may want to rapidly filter the output datasets for proteins that show good homology to proteins that have already been structurally characterised or proteins that are already targe

SUBMITTER: Toomey D 

PROVIDER: S-EPMC2704375 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature