Involvement of the post-transcriptional regulator Hfq in Yersinia pestis virulence.

ABSTRACT:

Background

Yersinia pestis is the causative agent of plague, which is transmitted primarily between fleas and mammals and is spread to humans through the bite of an infected flea or contact with afflicted animals. Hfq is proposed to be a global post-transcriptional regulator that acts by mediating interactions between many regulatory small RNAs (sRNAs) and their mRNA targets. Sequence comparisons revealed that Y. pestis appears to produce a functional homologue of E. coli Hfq.

Methodology and principal findings

Phenotype comparisons using in vitro assays demonstrated that Y. pestis Hfq was involved in resistance to H(2)O(2), heat and polymyxin B and contributed to growth under nutrient-limiting conditions. The role of Hfq in Y. pestis virulence was also assessed using macrop

SUBMITTER: Geng J 

PROVIDER: S-EPMC2704395 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature