Association of variants in DISC1 with psychosis-related traits in a large population cohort.

ABSTRACT:

Context

There is an abundance of data from human genetic studies and animal models that implies a role for the disrupted in schizophrenia 1 gene (DISC1) in the etiology of schizophrenia and other major mental illnesses.

Objective

To study the effect of previously identified risk alleles of DISC1 on quantitative intermediate phenotypes for psychosis in an unselected population.

Design

We examined 41 single-nucleotide polymorphisms within DISC1 and performed tests of association with 4 quantitative phenotypes.

Setting

Academic research.

Participants

Individuals from an unselected birth cohort in Finland. Originally, everyone born in the catchment area in 1966 (N = 12 058) was included in the study. Of these, 4651 (38.6%) attended the 31-year follow-up and

SUBMITTER: Tomppo L 

PROVIDER: S-EPMC2704396 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature