Hypersusceptibility to azole antifungals in a clinical isolate of Candida glabrata with reduced aerobic growth.

ABSTRACT: Petite mutations have been described in Saccharomyces cerevisiae and pathogenic yeasts. However, previous studies of the phenotypic traits of these petite mutants reported that they express azole resistance. We describe a clinical isolate of Candida glabrata with a striking association between increased susceptibility to azoles and respiratory deficiency. This isolate was obtained from a urine sample together with a respiration-competent C. glabrata isolate which exhibited azole resistance. The respiratory status of the two isolates was confirmed by cultivation on glycerol-containing agar and oxygraphy. Flow cytometry revealed the normal incorporation of rhodamine 123, and mitochondrial sections with typical cristae were seen by transmission electron microscopy for both isolates. Together,

SUBMITTER: Vandeputte P 

PROVIDER: S-EPMC2704708 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature