Chemicals possessing a neurotrophin-like activity on dopaminergic neurons in primary culture.

ABSTRACT:

Background

Neurotrophic factors have been shown to possess strong neuroprotective and neurorestaurative properties in Parkinson's disease patients. However the issues to control their delivery into the interest areas of the brain and their surgical administration linked to their unability to cross the blood brain barrier are many drawbacks responsible of undesirable side effects limiting their clinical use. A strategy implying the use of neurotrophic small molecules could provide an interesting alternative avoiding neurotrophin administration and side effects. In an attempt to develop drugs mimicking neurotrophic factors, we have designed and synthesized low molecular weight molecules that exhibit neuroprotective and neuritogenic potential for dopaminergic neurons.

Principal fin

SUBMITTER: Schmidt F 

PROVIDER: S-EPMC2704893 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature