Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome.

ABSTRACT: The bacterial cell-envelope consists of a complex arrangement of lipids, proteins and carbohydrates that serves as the interface between a microorganism and its environment or, with pathogens, a human host. Escherichia coli has long been investigated as a leading model system to elucidate the fundamental mechanisms underlying microbial cell-envelope biology. This includes extensive descriptions of the molecular identities, biochemical activities and evolutionary trajectories of integral transmembrane proteins, many of which play critical roles in infectious disease and antibiotic resistance. Strikingly, however, only half of the c. 1200 putative cell-envelope-related proteins of E. coli currently have experimentally attributed functions, indicating an opportunity for discovery. In this rev

SUBMITTER: Diaz-Mejia JJ 

PROVIDER: S-EPMC2704936 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature