Detection of cancer with serum miRNAs on an oligonucleotide microarray.

ABSTRACT: Micro RNAs (miRNAs) are a class of small, non-coding RNA species that play critical roles throughout cellular development and regulation. miRNA expression patterns taken from various tissue types often point to the cellular lineage of an individual tissue type, thereby being a more invariant hallmark of tissue type. Recent work has shown that these miRNA expression patterns can be used to classify tumor cells, and that this classification can be more accurate than the classification achieved by using messenger RNA gene expression patterns. One aspect of miRNA biogenesis that makes them particularly attractive as a biomarker is the fact that they are maintained in a protected state in serum and plasma, thus allowing the detection of miRNA expression patterns directly from serum. This study

SUBMITTER: Lodes MJ 

PROVIDER: S-EPMC2704963 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature