Relating periodicity of nucleosome organization and gene regulation.

ABSTRACT:

Motivation

The relationship between nucleosome positioning and gene regulation is fundamental yet complex. Previous studies on genomic nucleosome positions have revealed a correlation between nucleosome occupancy on promoters and gene expression levels. Many of these studies focused on individual nucleosomes, especially those proximal to transcription start sites. To study the collective effect of multiple nucleosomes on the gene expression, we developed a mathematical approach based on autocorrelation to relate genomic nucleosome organization to gene regulation.

Results

We found that nucleosome organization in gene promoters can be well described by autocorrelation transformation. Some promoters show obvious periods in their nucleosome organization, while others have no cle

SUBMITTER: Wan J 

PROVIDER: S-EPMC2705233 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature