Identification of previously unrecognized antiestrogenic chemicals using a novel virtual screening approach.

ABSTRACT: The physiological roles of estrogen in sexual differentiation and development, female and male reproductive processes, and bone health are complex and diverse. Numerous natural and synthetic chemical compounds, commonly known as endocrine disrupting chemicals (EDCs), have been shown to alter the physiological effects of estrogen in humans and wildlife. As such, these EDCs may cause unanticipated and even undesirable effects. Large-scale in vitro and in vivo screening of chemicals to assess their estrogenic activity would demand a prodigious investment of time, labor, and money and would require animal testing on an unprecedented scale. Approaches in silico are increasingly recognized as playing a vital role in screening and prioritizing chemicals to extend limited resources available for e

SUBMITTER: Wang CY 

PROVIDER: S-EPMC2705242 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature