Exercise-induced up-regulation of MMP-1 and IL-8 genes in endurance horses.

ABSTRACT:

Background

The stress response is a critical factor in the training of equine athletes; it is important for performance and for protection of the animal against physio-pathological disorders.In this study, the molecular mechanisms involved in the response to acute and strenuous exercise were investigated using peripheral blood mononuclear cells (PBMCs).

Results

Quantitative real-time PCR (qRT-PCR) was used to detect modifications in transcription levels of the genes for matrix metalloproteinase-1 (MMP-1) and interleukin 8 (IL-8), which were derived from previous genome-wide expression analysis. Significant up-regulation of these two genes was found in 10 horses that had completed a race of 90-120 km in a time-course experimental design.

Conclusion

These results sugges

SUBMITTER: Cappelli K 

PROVIDER: S-EPMC2705340 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature