On the functional diversity of dynamical behaviour in genetic and metabolic feedback systems.

ABSTRACT:

Background

Feedback regulation plays crucial roles in the robust control and maintenance of many cellular systems. Negative feedbacks are found to underline both stable and unstable, often oscillatory, behaviours. We explore the dynamical characteristics of systems with single as well as coupled negative feedback loops using a combined approach of analytical and numerical techniques. Particularly, we emphasise how the loop's characterising factors (strength and cooperativity levels) affect system dynamics and how individual loops interact in the coupled-loop systems.

Results

We develop an analytical bifurcation analysis based on the stability and the Routh-Hurwitz theorem for a common negative feedback system and a variety of its variants. We demonstrate that different combi

SUBMITTER: Nguyen LK 

PROVIDER: S-EPMC2705352 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature