Patterns of GATA3 and IL13 gene polymorphisms associated with childhood rhinitis and atopy in a birth cohort.

ABSTRACT:

Background

GATA3 activates transcription of the T(H)2 cytokines, including IL13, an important step in the allergic inflammatory pathway.

Objective

We sought to identify associations of single nucleotide polymorphisms of the genes GATA3 and IL13 and their interactions with rhinitis and allergic sensitization during childhood.

Methods

We performed genetic association studies in a cohort of children (n = 923) who have been evaluated for the development of rhinitis and allergic sensitization by means of skin prick tests (SPTs) at age 10 years. Pyrosequencing was used to genotype 7 polymorphisms from GATA3 and 5 from IL13. A novel model-selection procedure combining logistic regression models and classification was used to study the contributions of the polymorphisms and t

SUBMITTER: Huebner M 

PROVIDER: S-EPMC2705662 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature