ProteinArchitect: protein evolution above the sequence level.

ABSTRACT:

Background

While many authors have discussed models and tools for studying protein evolution at the sequence level, molecular function is usually mediated by complex, higher order features such as independently folding domains and linear motifs that are based on or embedded in a particular arrangment of features such as secondary structure elements, transmembrane domains and regions with intrinsic disorder. This 'protein architecture' can, in its most simplistic representation, be visualized as domain organization cartoons that can be used to compare proteins in terms of the order of their mostly globular domains.

Methodology

Here, we describe a visual approach and a webserver for protein comparison that extend the domain organization cartoon concept. By developing an inform

SUBMITTER: Haimel M 

PROVIDER: S-EPMC2705671 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature