A comprehensive analysis of the structure-function relationship in proteins based on local structure similarity.

ABSTRACT:

Background

Sequence similarity to characterized proteins provides testable functional hypotheses for less than 50% of the proteins identified by genome sequencing projects. With structural genomics it is believed that structural similarities may give functional hypotheses for many of the remaining proteins.

Methodology/principal findings

We provide a systematic analysis of the structure-function relationship in proteins using the novel concept of local descriptors of protein structure. A local descriptor is a small substructure of a protein which includes both short- and long-range interactions. We employ a library of commonly reoccurring local descriptors general enough to assemble most existing protein structures. We then model the relationship between these local shapes a

SUBMITTER: Hvidsten TR 

PROVIDER: S-EPMC2705683 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature