A comparative proteomic analysis of the simple amino acid repeat distributions in Plasmodia reveals lineage specific amino acid selection.

ABSTRACT:

Background

Microsatellites have been used extensively in the field of comparative genomics. By studying microsatellites in coding regions we have a simple model of how genotypic changes undergo selection as they are directly expressed in the phenotype as altered proteins. The simplest of these tandem repeats in coding regions are the tri-nucleotide repeats which produce a repeat of a single amino acid when translated into proteins. Tri-nucleotide repeats are often disease associated, and are also known to be unstable to both expansion and contraction. This makes them sensitive markers for studying proteome evolution, in closely related species.

Results

The evolutionary history of the family of malarial causing parasites Plasmodia is complex because of the life-cycle of the o

SUBMITTER: Dalby AR 

PROVIDER: S-EPMC2705789 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature