Regulation of interactions with sliding clamps during DNA replication and repair.

ABSTRACT: The molecular machines that replicate the genome consist of many interacting components. Essential to the organization of the replication machinery are ring-shaped proteins, like PCNA (Proliferating Cell Nuclear Antigen) or the beta- clamp, collectively named sliding clamps. They encircle the DNA molecule and slide on it freely and bidirectionally. Sliding clamps are typically associated to DNA polymerases and provide these enzymes with the processivity required to synthesize large chromosomes. Additionally, they interact with a large array of proteins that perform enzymatic reactions on DNA, targeting and orchestrating their functions. In recent years there have been a large number of studies that have analyzed the structural details of how sliding clamps interact with their ligands. Howe

SUBMITTER: Lopez de Saro FJ 

PROVIDER: S-EPMC2705854 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature