Definition, conservation and epigenetics of housekeeping and tissue-enriched genes.

ABSTRACT:

Background

Housekeeping genes (HKG) are constitutively expressed in all tissues while tissue-enriched genes (TEG) are expressed at a much higher level in a single tissue type than in others. HKGs serve as valuable experimental controls in gene and protein expression experiments, while TEGs tend to represent distinct physiological processes and are frequently candidates for biomarkers or drug targets. The genomic features of these two groups of genes expressed in opposing patterns may shed light on the mechanisms by which cells maintain basic and tissue-specific functions.

Results

Here, we generate gene expression profiles of 42 normal human tissues on custom high-density microarrays to systematically identify 1,522 HKGs and 975 TEGs and compile a small subset of 20 housekeep

SUBMITTER: She X 

PROVIDER: S-EPMC2706266 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature