Serotonin modulation of cerebral glucose metabolism in depressed older adults.

ABSTRACT:

Background

Monoamine dysfunction, particularly of the serotonin system, has been the dominant hypothesis guiding research and treatment development in affective disorders. The majority of research has been performed in midlife depressed adults. The importance of understanding the neurobiology of depression in older adults is underscored by increased rates of mortality and completed suicide and an increased risk of Alzheimer's dementia. To evaluate the dynamic response of the serotonin system, the acute effects of citalopram infusion on cerebral glucose metabolism was measured in depressed older adults and control subjects. The hypothesis was tested that smaller decreases in metabolism would be observed in cortical and limbic regions in depressed older adults relative to control sub

SUBMITTER: Smith GS 

PROVIDER: S-EPMC2706292 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature