Maternal and fetal variation in genes of cholesterol metabolism is associated with preterm delivery.

ABSTRACT:

Objective

To examine the contribution of variants in fetal and maternal cholesterol metabolism genes in preterm delivery (PTD).

Study design

A total of 40 single-nucleotide polymorphisms (SNPs) in 16 genes related to cholesterol metabolism were examined for 414 preterm infants (gestational ages 22 to 36 weeks; comprising 305 singletons and 109 twins) and at least 1 parent. Fetal effects were assessed using the transmission disequilibrium test (TDT) for each SNP, followed by a log linear model-based approach to utilize families with missing parental genotypes for those SNPs showing significance under TDT. Genetic variant effects were examined for a role in PTD, gestational age and birth weight. Maternal effects were estimated using a log linear model-based approach.

Result

SUBMITTER: Steffen KM 

PROVIDER: S-EPMC2706423 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature