Stochastic modelling of nucleocytoplasmic oscillations of the transcription factor Msn2 in yeast.

ABSTRACT: Stress induces oscillatory nucleocytoplasmic shuttling of the transcription factor Msn2 in yeast. The subcellular localization of Msn2 is controlled by the cAMP-dependent protein kinase, PKA. Recent experimental observations corroborated by a deterministic computational model for the cAMP-PKA pathway in yeast suggest that the oscillatory dynamics of Msn2 results from the periodic activation of PKA associated with stress-induced oscillations in the level of cAMP. The model accounts for the occurrence of oscillations of Msn2 in a window bounded by two critical values of the stress intensity. In contrast to the rather irregular oscillatory behaviour observed within single yeast cells by means of fluorescence measurements, the deterministic model can only produce a regular pattern of oscillati

SUBMITTER: Gonze D 

PROVIDER: S-EPMC2706453 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature