Adaptive dynamics with a single two-state protein.

ABSTRACT: An important step towards understanding biological systems is to relate simple biochemical elements to dynamics. Here, we present the arguably simplest dynamical element in biochemical networks. It consists of a single protein with two states (active and inactive) and an external signal that catalyses the conversion between these two states. Further, there is steady synthesis and degradation of the inactive and active forms, respectively. As this element captures both structural and dynamical features of biochemical networks at the lowest level, we refer to it as a biochemical network unit (BioNetUnit). Using both simulations and mathematical analysis, we find that BioNetUnit shows perfect adaptation that leads to temporal responses to step changes in the incoming signal. Compared with a w

SUBMITTER: Csikasz-Nagy A 

PROVIDER: S-EPMC2706455 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature