Mapping global sensitivity of cellular network dynamics: sensitivity heat maps and a global summation law.

ABSTRACT: The dynamical systems arising from gene regulatory, signalling and metabolic networks are strongly nonlinear, have high-dimensional state spaces and depend on large numbers of parameters. Understanding the relation between the structure and the function for such systems is a considerable challenge. We need tools to identify key points of regulation, illuminate such issues as robustness and control and aid in the design of experiments. Here, I tackle this by developing new techniques for sensitivity analysis. In particular, I show how to globally analyse the sensitivity of a complex system by means of two new graphical objects: the sensitivity heat map and the parameter sensitivity spectrum. The approach to sensitivity analysis is global in the sense that it studies the variation in the who

SUBMITTER: Rand DA 

PROVIDER: S-EPMC2706458 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature