Genomic characterization of the human mitochondrial tumor suppressor gene 1 (MTUS1): 5' cloning and preliminary analysis of the multiple gene promoters.

ABSTRACT:

Background

Mitochondrial tumor suppressor gene 1 (MTUS1) has been recently identified as a candidate tumor suppressor gene which resides in a genomic region (8p22) that shows frequent loss of heterozygosity (LOH) in several tumor types. It has been suggested that multiple gene promoters and alternative splicing lead to the expression of 5 known MTUS1 transcript variants.

Findings

Here, we characterized the 5' untranslated regions of the different transcript variants. We also cloned and functionally tested the alternatively utilized gene promoters that contribute to the production of different MTUS1 transcript variants.

Conclusion

Our results confirmed the early hypothesis that the transcript variants of MTUS1 gene are driven by multiple gene promoters.

SUBMITTER: Yu J 

PROVIDER: S-EPMC2706840 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature