Host cell transcriptional profiling during malaria liver stage infection reveals a coordinated and sequential set of biological events.

ABSTRACT:

Background

Plasmodium sporozoites migrate to the liver where they traverse several hepatocytes before invading the one inside which they will develop and multiply into thousands of merozoites. Although this constitutes an essential step of malaria infection, the requirements of Plasmodium parasites in liver cells and how they use the host cell for their own survival and development are poorly understood.

Results

To gain new insights into the molecular host-parasite interactions that take place during malaria liver infection, we have used high-throughput microarray technology to determine the transcriptional profile of P. berghei-infected hepatoma cells. The data analysis shows differential expression patterns for 1064 host genes starting at 6 h and up to 24 h post infection,

SUBMITTER: Albuquerque SS 

PROVIDER: S-EPMC2706893 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature