Virus-host coevolution: common patterns of nucleotide motif usage in Flaviviridae and their hosts.

ABSTRACT: Virus-host biological interaction is a continuous coevolutionary process involving both host immune system and viral escape mechanisms. Flaviviridae family is composed of fast evolving RNA viruses that infects vertebrate (mammals and birds) and/or invertebrate (ticks and mosquitoes) organisms. These host groups are very distinct life forms separated by a long evolutionary time, so lineage-specific anti-viral mechanisms are likely to have evolved. Flaviviridae viruses which infect a single host lineage would be subjected to specific host-induced pressures and, therefore, selected by them. In this work we compare the genomic evolutionary patterns of Flaviviridae viruses and their hosts in an attempt to uncover coevolutionary processes inducing common features in such disparate groups. Especi

SUBMITTER: Lobo FP 

PROVIDER: S-EPMC2707012 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature