A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study.

ABSTRACT:

Background

Genetic subtypes of acute lymphoblastic leukaemia (ALL) are used to determine risk and treatment in children. 25% of precursor B-ALL cases are genetically unclassified and have intermediate prognosis. We aimed to use a genome-wide study to improve prognostic classification of ALL in children.

Methods

We constructed a classifier based on gene expression in 190 children with newly diagnosed ALL (German Cooperative ALL [COALL] discovery cohort) by use of double-loop cross-validation and validated this in an independent cohort of 107 newly diagnosed patients (Dutch Childhood Oncology Group [DCOG] independent validation cohort). Hierarchical cluster analysis with classifying gene-probe sets revealed a new ALL subtype, the underlying genetic abnormalities of which were

SUBMITTER: Den Boer ML 

PROVIDER: S-EPMC2707020 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature