The potential for signal integration and processing in interacting MAP kinase cascades.

ABSTRACT: The cellular response to environmental stimuli requires biochemical information processing through which sensory inputs and cellular status are integrated and translated into appropriate responses by way of interacting networks of enzymes. One such network, the mitogen-activated protein (MAP) kinase cascade is a highly conserved signal transduction module that propagates signals from cell surface receptors to various cytosolic and nuclear targets by way of a phosphorylation cascade. We have investigated the potential for signal processing within a network of interacting feed-forward kinase cascades typified by the MAP kinase cascade. A genetic algorithm was used to search for sets of kinetic parameters demonstrating representative key input-output patterns of interest. We discuss two of th

SUBMITTER: Schwacke JH 

PROVIDER: S-EPMC2707083 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature