System theoretical investigation of human epidermal growth factor receptor-mediated signalling.

ABSTRACT: The partitioning of biological networks into coupled-functional modules is being increasingly applied for developing predictive models of biological systems. This approach has the advantage that predicting a system-level response does not require a mechanistic description of the internal dynamics of each module. Identification of the input-output characteristics of the network modules and the connectivity between the modules provide the necessary quantitative representation of system dynamics. However, the determination of the input-output relationships of the modules is not trivial; it requires the controlled perturbation of module inputs and systematic analysis of experimental data. In this report, the authors apply a system theoretical analysis approach to derive the time-dependent inpu

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC2707181 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature