The gene expression signature of genomic instability in breast cancer is an independent predictor of clinical outcome.

ABSTRACT: Recently, expression profiling of breast carcinomas has revealed gene signatures that predict clinical outcome, and discerned prognostically relevant breast cancer subtypes. Measurement of the degree of genomic instability provides a very similar stratification of prognostic groups. We therefore hypothesized that these features are linked. We used gene expression profiling of 48 breast cancer specimens that profoundly differed in their degree of genomic instability and identified a set of 12 genes that defines the 2 groups. The biological and prognostic significance of this gene set was established through survival prediction in published datasets from patients with breast cancer. Of note, the gene expression signatures that define specific prognostic subtypes in other breast cancer datase

SUBMITTER: Habermann JK 

PROVIDER: S-EPMC2707256 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature