Analyzing miRNA co-expression networks to explore TF-miRNA regulation.

ABSTRACT:

Background

Current microRNA (miRNA) research in progress has engendered rapid accumulation of expression data evolving from microarray experiments. Such experiments are generally performed over different tissues belonging to a specific species of metazoan. For disease diagnosis, microarray probes are also prepared with tissues taken from similar organs of different candidates of an organism. Expression data of miRNAs are frequently mapped to co-expression networks to study the functions of miRNAs, their regulation on genes and to explore the complex regulatory network that might exist between Transcription Factors (TFs), genes and miRNAs. These directions of research relating miRNAs are still not fully explored, and therefore, construction of reliable and compatible methods for min

SUBMITTER: Bandyopadhyay S 

PROVIDER: S-EPMC2707367 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature