Sleep-dependent gene expression in the hippocampus and prefrontal cortex following long-term potentiation.

ABSTRACT: The activity-dependent transcription factor zif268 is re-activated in sleep following hippocampal long-term potentiation (LTP). However, the activation of secondary genes, possibly involved in modifying local synaptic strengths and ultimately stabilizing memory traces during sleep, has not yet been studied. Here, we investigated changes in hippocampal and cortical gene expression at a time point subsequent to the previously reported initial zif268 re-activation during sleep. Rats underwent unilateral hippocampal LTP and were assigned to SLEEP or AWAKE groups. Eighty minutes after a long rapid-eye-movement sleep (REMS) episode (or an equivalent amount of time for awake group) animals had their hippocampi dissected and processed for gene microarray hybridization. Prefrontal and parietal cort

SUBMITTER: Romcy-Pereira RN 

PROVIDER: S-EPMC2707503 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature