Ontology highlight
ABSTRACT:
SUBMITTER: Lehar J
PROVIDER: S-EPMC2708317 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Nature biotechnology 20090705 7
Drug combinations are a promising strategy to overcome the compensatory mechanisms and unwanted off-target effects that limit the utility of many potential drugs. However, enthusiasm for this approach is tempered by concerns that the therapeutic synergy of a combination will be accompanied by synergistic side effects. Using large scale simulations of bacterial metabolism and 94,110 multi-dose experiments relevant to diverse diseases, we provide evidence that synergistic drug combinations are gen ...[more]