Identification of glutathione S-transferase pi as a protein involved in Parkinson disease progression.

ABSTRACT: Parkinson disease (PD) typically affects the cortical regions during the later stages of disease, with neuronal loss, gliosis, and formation of diffuse cortical Lewy bodies in a significant portion of patients with dementia. To identify novel proteins involved in PD progression, we prepared synaptosomal fractions from the frontal cortices of pathologically verified PD patients at different stages along with age-matched controls. Protein expression profiles were compared using a robust quantitative proteomic technique. Approximately 100 proteins displayed significant differences in their relative abundances between PD patients at various stages and controls; three of these proteins were validated using independent techniques. One of the confirmed proteins, glutathione S-transferase Pi, was

SUBMITTER: Shi M 

PROVIDER: S-EPMC2708794 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature