Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer.

ABSTRACT: This study systematically analyzes platelet-derived growth factor (PDGF) receptor expression in six types of common tumors as well as examines associations between PDGF beta-receptor status and clinicopathological characteristics in breast cancer. PDGF receptor expression was determined by immunohistochemistry on tumor tissue microarrays. Breast tumor data were combined with prognostic factors and related to outcome endpoints. PDGF alpha- and beta-receptors were independently expressed, at variable frequencies, in the tumor stroma of all tested tumor types. There was a significant association between PDGF beta-receptor expression on fibroblasts and perivascular cells in individual colon and prostate tumors. In breast cancer, high stromal PDGF beta-receptor expression was significantly asso

SUBMITTER: Paulsson J 

PROVIDER: S-EPMC2708819 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature