Effects of teriparatide retreatment in osteoporotic men and women.

ABSTRACT:

Context

The stimulatory effect of teriparatide on bone mineral density (BMD) and bone turnover is initially exuberant, but then diminishes.

Objective

Our objective was to determine whether retreating with teriparatide after a drug-free period can restore the initial exuberant response to teriparatide.

Design and setting

This was a planned extension of a randomized controlled trial conducted in a single university hospital.

Patients and intervention

Subjects previously participated in a 30-month randomized trial comparing the effects of alendronate (group 1), teriparatide (group 2), or both (group 3) on BMD and bone turnover in men and women with low BMD (phase 1). Subjects who completed phase 1 on their assigned therapy entered phase 2 (months 30-42), during wh

SUBMITTER: Finkelstein JS 

PROVIDER: S-EPMC2708954 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature