A recently evolved novel trophoblast-enriched secreted form of fms-like tyrosine kinase-1 variant is up-regulated in hypoxia and preeclampsia.

ABSTRACT:

Context

Recent published studies indicate a possible role for sFlt1 in the development of preeclampsia.

Objective

The objective of the study was to investigate the expression and regulation of sFlt1-e15a, a recently described novel C-terminal variant isoform of sFlt1.

Design

The studies included a computational comparative analysis of the genomic locus of sFlt1 across vertebrate species; an assessment of sFlt1 variants in human and rhesus cells and tissues; an analysis of sFlt1 variants transiently expressed in HeLa and COS-7 cells; an evaluation of the effect of hypoxia on sFlt1 expression in trophoblasts; and a comparison of placental sFlt1 expression between pregnancies complicated by preeclampsia and control pregnancies.

Result and conclusions

sFlt1-e15a em

SUBMITTER: Thomas CP 

PROVIDER: S-EPMC2708964 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature