Investigation of the association between the GLC3A locus and normal tension glaucoma in Japanese patients by microsatellite analysis.

ABSTRACT:

Purpose

To investigate whether the GLC3A locus harboring the CYP1B1 gene is associated with normal tension glaucoma (NTG) in Japanese patients.

Materials and methods

One hundred forty-two Japanese patients with NTG and 101 Japanese healthy controls were recruited. Patients exhibiting a comparatively early onset were selected as this suggests that genetic factors may show stronger involvement. Genotyping and assessment of allelic diversity was performed on 13 highly polymorphic microsatellite markers in and around the GLC3A locus.

Results

There were decreased frequencies of the 444 allele of D2S0416i and the 258 allele of D2S0425i in cases compared to controls (P = 0.022 and P = 0.034, respectively). However, this statistical significance disappeared when corrected (Pc

SUBMITTER: Kamio M 

PROVIDER: S-EPMC2708983 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature