Association of microsatellite polymorphisms of the GPDS1 locus with normal tension glaucoma in the Japanese population.

ABSTRACT:

Background

To investigate whether the GPDS1 locus, a potential causative locus of pigment-dispersion syndrome, is associated with normal-tension glaucoma (NTG) in Japanese patients.

Materials and methods

We used polymerase chain reaction amplification with sequence-specific primers to analyze 20 polymorphic microsatellite markers in and around the GPDS1 locus with an automated DNA analyzer and automated fragment detection by fluorescent-based technology. The DNA samples used for these analyses were obtained from ethnicity- and gender-matched patients, including 141 Japanese patients with NTG and 101 healthy controls. Patients exhibiting a comparatively early onset were selected as this suggests that genetic factors may show stronger involvement.

Results

One allele of

SUBMITTER: Nakamura K 

PROVIDER: S-EPMC2708999 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature