Unfoldomics of human diseases: linking protein intrinsic disorder with diseases.

ABSTRACT:

Background

Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) lack stable tertiary and/or secondary structure yet fulfills key biological functions. The recent recognition of IDPs and IDRs is leading to an entire field aimed at their systematic structural characterization and at determination of their mechanisms of action. Bioinformatics studies showed that IDPs and IDRs are highly abundant in different proteomes and carry out mostly regulatory functions related to molecular recognition and signal transduction. These activities complement the functions of structured proteins. IDPs and IDRs were shown to participate in both one-to-many and many-to-one signaling. Alternative splicing and posttranslational modifications are frequently used to tune the

SUBMITTER: Uversky VN 

PROVIDER: S-EPMC2709268 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature