Investigation of parent-of-origin effect in comitant strabismus using MOD score analysis.

ABSTRACT:

Purpose

Comitant strabismus is a common pediatric ophthalmic disorder with both genetic and non-genetic factors contributing to its etiology. The aim of the current study is to investigate the phenomenon of a parent-of-origin effect, genomic imprinting, as a possible mode of inheritance in comitant strabismus.

Methods

We performed parametric genome-wide MOD score (model-maximized LOD score) linkage analysis, incorporating imprinting effects, for 382 microsatellite markers in a sample of 258 individuals (117 males and 141 females) from 55 Japanese families with comitant strabismus. We included individuals as affected patients if they presented with comitant esotropia or exotropia based on ophthalmic examination, history taking, or analysis of medical records.

Results

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SUBMITTER: Shaaban S 

PROVIDER: S-EPMC2709426 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature