Contrast-induced nephropathy and long-term adverse events: cause and effect?

ABSTRACT:

Background and objectives

The relationship of contrast-induced nephropathy (CIN) to long-term adverse events (AEs) is controversial. Although an association with AEs has been previously reported, it is unclear whether CIN is causally related to these AEs.

Design, setting, participants, & measurements

We obtained long-term (> or =1 yr) follow-up on 294 patients who participated in a randomized, double-blind comparison of two prevention strategies for CIN (iopamidol versus iodixanol). A difference in the incidence of AEs between patients who had developed CIN and those who had not was performed using a chi(2) test and Poisson regression analysis. A similar statistical approach was used for the differences in AEs between those who received iopamidol or iodixanol. Multiple defin

SUBMITTER: Solomon RJ 

PROVIDER: S-EPMC2709519 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature