Differential gene expression in human cerebrovascular malformations.

ABSTRACT:

Objective

We sought to identify genes with differential expression in cerebral cavernous malformations (CCMs), arteriovenous malformations (AVMs), and control superficial temporal arteries (STAs) and to confirm differential expression of genes previously implicated in the pathobiology of these lesions.

Methods

Total ribonucleic acid was isolated from four CCM, four AVM, and three STA surgical specimens and used to quantify lesion-specific messenger ribonucleic acid expression levels on human gene arrays. Data were analyzed with the use of two separate methodologies: gene discovery and confirmation analysis.

Results

The gene discovery method identified 42 genes that were significantly up-regulated and 36 genes that were significantly down-regulated in CCMs as compared

SUBMITTER: Shenkar R 

PROVIDER: S-EPMC2709524 | biostudies-literature | 2003 Feb

REPOSITORIES: biostudies-literature