Ontology highlight
ABSTRACT:
SUBMITTER: Kamalakaran S
PROVIDER: S-EPMC2709589 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Nucleic acids research 20090527 12
Methylation of CpG islands associated with genes can affect the expression of the proximal gene, and methylation of non-associated CpG islands correlates to genomic instability. This epigenetic modification has been shown to be important in many pathologies, from development and disease to cancer. We report the development of a novel high-resolution microarray that detects the methylation status of over 25,000 CpG islands in the human genome. Experiments were performed to demonstrate low system ...[more]