A complex-centric view of protein network evolution.

ABSTRACT: The recent availability of protein-protein interaction networks for several species makes it possible to study protein complexes in an evolutionary context. In this article, we present a novel network-based framework for reconstructing the evolutionary history of protein complexes. Our analysis is based on generalizing evolutionary measures for single proteins to the level of whole subnetworks, comprehensively considering a broad set of computationally derived complexes and accounting for both sequence and interaction changes. Specifically, we compute sets of orthologous complexes across species, and use these to derive evolutionary rate and age measures for protein complexes. We observe significant correlations between the evolutionary properties of a complex and those of its member prote

SUBMITTER: Yosef N 

PROVIDER: S-EPMC2709590 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature