Ontology highlight
ABSTRACT:
SUBMITTER: O'Connor W
PROVIDER: S-EPMC2709990 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Nature immunology 20090601 6
Interleukin 23 (IL-23) and IL-17 have been linked to the pathogenesis of several chronic inflammatory disorders, including inflammatory bowel disease. Yet as an important function for IL-23 is emerging, the function of IL-17 in inflammatory bowel disease remains unclear. Here we demonstrate IL-17A-mediated protection in the CD45RBhi transfer model of colitis. An accelerated wasting disease elicited by T cells deficient in IL-17A correlated with higher expression of genes encoding T helper type 1 ...[more]