Imaging rapid redistribution of sensory-evoked depolarization through existing cortical pathways after targeted stroke in mice.

ABSTRACT: Evidence suggests that recovery from stroke damage results from the production of new synaptic pathways within surviving brain regions over weeks. To address whether brain function might redistribute more rapidly through preexisting pathways, we examined patterns of sensory-evoked depolarization in mouse somatosensory cortex within hours after targeted stroke to a subset of the forelimb sensory map. Brain activity was mapped with voltage-sensitive dye imaging allowing millisecond time resolution over 9 mm(2) of brain. Before targeted stroke, we report rapid activation of the forelimb area within 10 ms of contralateral forelimb stimulation and more delayed activation of related areas of cortex such as the hindlimb sensory and motor cortices. After stroke to a subset of the forelimb somatose

SUBMITTER: Sigler A 

PROVIDER: S-EPMC2710634 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature