Ontology highlight
ABSTRACT:
SUBMITTER: Gregory SM
PROVIDER: S-EPMC2710638 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Gregory Sean M SM West John A JA Dillon Patrick J PJ Hilscher Chelsey C Dittmer Dirk P DP Damania Blossom B
Proceedings of the National Academy of Sciences of the United States of America 20090629 28
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman's disease. Like other herpesviruses, KSHV establishes life-long latency in the human host with intermittent periods of reactivation. Physiological triggers of herpesviral reactivation are poorly defined. Toll-like receptors (TLRs) recognize pathogens and are vital for the host innate immune response. We screened multiple TLR agonists for their a ...[more]